Bioavailability comparison of three controlled release codeine formulations vs. conventional oral codeine
نویسندگان
چکیده
منابع مشابه
Opioid disposition in human sweat after controlled oral codeine administration.
BACKGROUND Characterization of opioid excretion in sweat is important for accurate interpretation of sweat tests in drug treatment, criminal justice, and workplace drug testing programs. METHODS Participants (n=20) received placebo, 3 low (60 mg/70 kg) or 3 high (120 mg/70 kg) codeine sulfate doses (used as a model for opioid excretion) within 1 week. Codeine and metabolites in sweat were col...
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Hair testing for the determination of drug exposure has many useful applications. Drug incorporated into hair can be found for extended periods following drug exposure. There are few controlled drug administration studies investigating drug distribution into human hair. Ten volunteers participated in a 10-week controlled cocaine and codeine administration study while residing in the secure rese...
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A clinical study was designed to determine if there was a predictable relationship between saliva and plasma codeine concentrations. Drug-free volunteers (n = 17) were administered a 30-mg dose of liquid codeine phosphate. Plasma and saliva specimens were collected at various times for 24 h after administration. Plasma and saliva were analyzed for codeine and morphine by positive-ion chemical i...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 1988
ISSN: 0885-3924
DOI: 10.1016/0885-3924(88)90080-2